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Identification of Cisplatin-Binding Proteins Using Agarose Conjugates of Platinum Compounds

Cisplatin is widely used as an antineoplastic drug, but its ototoxic and nephrotoxic side-effects, as well as the inherent or acquired resistance of some cancers to cisplatin, remain significant clinical problems. Cisplatin's selectivity in killing rapidly proliferating cancer cells is largely...

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Detalhes bibliográficos
Main Authors: Karasawa, Takatoshi, Sibrian-Vazquez, Martha, Strongin, Robert M., Steyger, Peter S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670892/
https://ncbi.nlm.nih.gov/pubmed/23755301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066220
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