PI3Kα activates integrin α4β1 to establish a metastatic niche in lymph nodes

Lymph nodes are initial sites of tumor metastasis, yet whether the lymph node microenvironment actively promotes tumor metastasis remains unknown. We show here that VEGF-C/PI3Kα-driven remodeling of lymph nodes promotes tumor metastasis by activating integrin α4β1 on lymph node lymphatic endothelium...

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Detalhes bibliográficos
Main Authors: Garmy-Susini, Barbara, Avraamides, Christie J., Desgrosellier, Jay S., Schmid, Michael C., Foubert, Philippe, Ellies, Lesley G., Lowy, Andrew M., Blair, Sarah L., Vandenberg, Scott R., Datnow, Brian, Wang, Huan-You, Cheresh, David A., Varner, Judith
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670313/
https://ncbi.nlm.nih.gov/pubmed/23671068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219603110
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