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PI3Kγ activates integrin α4 promotes immune suppressive myeloid cell polarization during tumor progression
Immunosuppressive myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) accumulate in tumors where they inhibit T cell-mediated anti-tumor immune responses and promote tumor progression. Myeloid cell PI3Kγ plays a key role in regulating tumor immune suppression by promotin...
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| Publicado no: | Cancer Immunol Res |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6422969/ https://ncbi.nlm.nih.gov/pubmed/28963139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-17-0143 |
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