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Interaction of the oncogenic miR-21 microRNA and the p53 tumor suppressor pathway

MicroRNA-21 (miR-21) is overexpressed virtually in all human cancers and displays oncogenic activity in a transgenic murine model. Similarly, the p53 tumor suppressor gene is the most frequently mutated gene in human cancer, and its loss or mutation leads to tumor formation in mice. To ascertain the...

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Bibliografiske detaljer
Main Authors: Ma, Xiaodong, Choudhury, Saibyasachi N., Hua, Xiang, Dai, Zhongping, Li, Yong
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670255/
https://ncbi.nlm.nih.gov/pubmed/23385064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgt044
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