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Interaction of the oncogenic miR-21 microRNA and the p53 tumor suppressor pathway
MicroRNA-21 (miR-21) is overexpressed virtually in all human cancers and displays oncogenic activity in a transgenic murine model. Similarly, the p53 tumor suppressor gene is the most frequently mutated gene in human cancer, and its loss or mutation leads to tumor formation in mice. To ascertain the...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3670255/ https://ncbi.nlm.nih.gov/pubmed/23385064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgt044 |
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