Glucose Metabolism via the Pentose Phosphate Pathway, Glycolysis and Krebs Cycle in an Orthotopic Mouse Model of Human Brain Tumors

It has been hypothesized that increased flux through the pentose phosphate pathway (PPP) is required to support the metabolic demands of rapid malignant cell growth. Using an orthotopic mouse model of primary human glioblastoma (GBM) and a brain metastatic renal tumor of clear cell renal cell carcin...

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Main Authors: Marin-Valencia, Isaac, Cho, Steve K., Rakheja, Dinesh, Hatanpaa, Kimmo J., Kapur, Payal, Mashimo, Tomoyuki, Jindal, Ashish, Vemireddy, Vamsidhara, Good, Levi B., Raisanen, Jack, Sun, Xiankai, Mickey, Bruce, Choi, Changho, Takahashi, Masaya, Togao, Osamu, Pascual, Juan M., DeBerardinis, Ralph J., Maher, Elizabeth A., Malloy, Craig R., Bachoo, Robert M.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670098/
https://ncbi.nlm.nih.gov/pubmed/22383401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/nbm.2787
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