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A role for the MRN complex in ATR activation through TOPBP1 recruitment
The MRN (MRE11-RAD50-NBS1) complex has been implicated in many aspects of the DNA damage response. It has key roles in sensing and processing DNA double-strand breaks, as well as in activation of ATM (ataxia-telangiectasia mutated). We reveal a new function for MRN in ATR (ATM and RAD3-related) acti...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3669687/ https://ncbi.nlm.nih.gov/pubmed/23582259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.03.006 |
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