Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection

The protein kinases ataxia-telangiectasia mutated (ATM) and ATM-Rad3 related (ATR) are activated in response to DNA damage, genotoxic stress and virus infections. Here we show that during infection with wild-type adenovirus, ATR and its cofactors RPA32, ATRIP and TopBP1 accumulate at viral replicati...

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Detalhes bibliográficos
Main Authors: Carson, Christian T, Orazio, Nicole I, Lee, Darwin V, Suh, Junghae, Bekker-Jensen, Simon, Araujo, Felipe D, Lakdawala, Seema S, Lilley, Caroline E, Bartek, Jiri, Lukas, Jiri, Weitzman, Matthew D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666027/
https://ncbi.nlm.nih.gov/pubmed/19197236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.15
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