Hepatocyte Nuclear Factor 4 alpha Deletion Promotes Diethylnitrosamine-induced Hepatocellular Carcinoma in Mice

HNF4α, the master regulator of hepatocyte differentiation, has been recently shown to inhibit hepatocyte proliferation via unknown mechanisms. We investigated the mechanisms of HNF4α-induced inhibition of hepatocyte proliferation using a novel TAM-inducible, hepatocyte specific HNF4α knockdown mouse...

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Главные авторы: Walesky, Chad, Edwards, Genea, Borude, Prachi, Gunewardena, Sumedha, O’Neil, Maura, Yoo, Byunggil, Apte, Udayan
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3669646/
https://ncbi.nlm.nih.gov/pubmed/23315968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26251
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