Iron increases the susceptibility of multiple myeloma cells to bortezomib

Multiple myeloma is a malignant still incurable plasma cell disorder. Pharmacological treatment based on proteasome inhibition has improved patient outcome; however, bortezomib-resistance remains a major clinical problem. Inhibition of proteasome functionality affects cellular iron homeostasis and i...

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Main Authors: Campanella, Alessandro, Santambrogio, Paolo, Fontana, Francesca, Frenquelli, Michela, Cenci, Simone, Marcatti, Magda, Sitia, Roberto, Tonon, Giovanni, Camaschella, Clara
Format: Artigo
Sprog:Inglês
Udgivet: Ferrata Storti Foundation 2013
Fag:
Original Articles and Brief Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3669455/
https://ncbi.nlm.nih.gov/pubmed/23242599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.074872
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