Adoptively transferred TRAIL(+) T cells suppress GVHD and augment antitumor activity

Current strategies to suppress graft-versus-host disease (GVHD) also compromise graft-versus-tumor (GVT) responses. Furthermore, most experimental strategies to separate GVHD and GVT responses merely spare GVT function without actually enhancing it. We have previously shown that endogenously express...

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Main Authors: Ghosh, Arnab, Dogan, Yildirim, Moroz, Maxim, Holland, Amanda M., Yim, Nury L., Rao, Uttam K., Young, Lauren F., Tannenbaum, Daniel, Masih, Durva, Velardi, Enrico, Tsai, Jennifer J., Jenq, Robert R., Penack, Olaf, Hanash, Alan M., Smith, Odette M., Piersanti, Kelly, Lezcano, Cecilia, Murphy, George F., Liu, Chen, Palomba, M. Lia, Sauer, Martin G., Sadelain, Michel, Ponomarev, Vladimir, van den Brink, Marcel R.M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668849/
https://ncbi.nlm.nih.gov/pubmed/23676461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66301
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