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Lamin B1 mediates cell-autonomous neuropathology in a leukodystrophy mouse model

Adult-onset autosomal-dominant leukodystrophy (ADLD) is a progressive and fatal neurological disorder characterized by early autonomic dysfunction, cognitive impairment, pyramidal tract and cerebellar dysfunction, and white matter loss in the central nervous system. ADLD is caused by duplication of...

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Autors principals: Heng, Mary Y., Lin, Shu-Ting, Verret, Laure, Huang, Yong, Kamiya, Sherry, Padiath, Quasar S., Tong, Ying, Palop, Jorge J., Huang, Eric J., Ptácχek, Louis J., Fu, Ying-Hui
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668844/
https://ncbi.nlm.nih.gov/pubmed/23676464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66737
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