Rare Variant Association Testing for Next-Generation Sequencing Data via Hierarchical Clustering

OBJECTIVES: It is thought that a proportion of the genetic susceptibility to complex diseases is due to low-frequency and rare variants. Next-generation sequencing in large populations facilitates the detection of rare variant associations to disease risk. In order to achieve adequate power to detec...

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Bibliographic Details
Main Authors: Tachmazidou, Ioanna, Morris, Andrew, Zeggini, Eleftheria
Format: Artigo
Language:Inglês
Published: S. Karger AG 2013
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Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668801/
https://ncbi.nlm.nih.gov/pubmed/23594494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000346022
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