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Rare Variant Association Testing for Next-Generation Sequencing Data via Hierarchical Clustering
OBJECTIVES: It is thought that a proportion of the genetic susceptibility to complex diseases is due to low-frequency and rare variants. Next-generation sequencing in large populations facilitates the detection of rare variant associations to disease risk. In order to achieve adequate power to detec...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
S. Karger AG
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3668801/ https://ncbi.nlm.nih.gov/pubmed/23594494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000346022 |
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