Engineering improved T cell receptors using an alanine-scan guided T cell display selection system

T cell receptors (TCRs) on T cells recognize peptide-major histocompatibility complex (pMHC) molecules on the surface of antigen presenting cells and this interaction determines the T cell immune response. Due to negative selection, naturally occurring TCRs bind self (tumor) peptides with low affini...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Malecek, Karolina, Zhong, Shi, McGary, Katelyn, Yu, Connie, Huang, Kevin, Johnson, Laura A, Rosenberg, Steven A., Krogsgaard, Michelle
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668434/
https://ncbi.nlm.nih.gov/pubmed/23500145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jim.2013.02.018
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky