T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy

T cells expressing antigen-specific T-cell receptors (TCRs) can mediate effective tumor regression, but they often also are accompanied by autoimmune responses. To determine the TCR affinity threshold defining the optimal balance between effective antitumor activity and autoimmunity in vivo, we used...

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Bibliographische Detailangaben
Hauptverfasser: Zhong, Shi, Malecek, Karolina, Johnson, Laura A., Yu, Zhiya, Vega-Saenz de Miera, Eleazar, Darvishian, Farbod, McGary, Katelyn, Huang, Kevin, Boyer, Josh, Corse, Emily, Shao, Yongzhao, Rosenberg, Steven A., Restifo, Nicholas P., Osman, Iman, Krogsgaard, Michelle
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637771/
https://ncbi.nlm.nih.gov/pubmed/23576742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1221609110
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