T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy

T cells expressing antigen-specific T-cell receptors (TCRs) can mediate effective tumor regression, but they often also are accompanied by autoimmune responses. To determine the TCR affinity threshold defining the optimal balance between effective antitumor activity and autoimmunity in vivo, we used...

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Main Authors: Zhong, Shi, Malecek, Karolina, Johnson, Laura A., Yu, Zhiya, Vega-Saenz de Miera, Eleazar, Darvishian, Farbod, McGary, Katelyn, Huang, Kevin, Boyer, Josh, Corse, Emily, Shao, Yongzhao, Rosenberg, Steven A., Restifo, Nicholas P., Osman, Iman, Krogsgaard, Michelle
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637771/
https://ncbi.nlm.nih.gov/pubmed/23576742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1221609110
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