T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy

T cells expressing antigen-specific T-cell receptors (TCRs) can mediate effective tumor regression, but they often also are accompanied by autoimmune responses. To determine the TCR affinity threshold defining the optimal balance between effective antitumor activity and autoimmunity in vivo, we used...

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Detalhes bibliográficos
Main Authors: Zhong, Shi, Malecek, Karolina, Johnson, Laura A., Yu, Zhiya, Vega-Saenz de Miera, Eleazar, Darvishian, Farbod, McGary, Katelyn, Huang, Kevin, Boyer, Josh, Corse, Emily, Shao, Yongzhao, Rosenberg, Steven A., Restifo, Nicholas P., Osman, Iman, Krogsgaard, Michelle
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637771/
https://ncbi.nlm.nih.gov/pubmed/23576742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1221609110
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