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Tumor Necrosis Factor-induced Toxic Liver Injury Results from JNK2-dependent Activation of Caspase-8 and the Mitochondrial Death Pathway()

In vitro studies of hepatocytes have implicated over-activation of c-Jun N-terminal kinase (JNK) signaling as a mechanism of tumor necrosis factor-α (TNF)-induced apoptosis. However, the functional significance of JNK activation and the role of specific JNK isoforms in TNF-induced hepatic apoptosis...

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Detalhes bibliográficos
Main Authors: Wang, Yongjun, Singh, Rajat, Lefkowitch, Jay H., Rigoli, Raina M., Czaja, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668334/
https://ncbi.nlm.nih.gov/pubmed/16571730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M512953200
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