Caspase-8 Is an Effector in Apoptotic Death of Dopaminergic Neurons in Parkinson's Disease, But Pathway Inhibition Results in Neuronal Necrosis

Caspase-8 is a proximal effector protein of the tumor necrosis factor receptor family death pathway. In the present human postmortem study, we observed a significantly higher percentage of dopaminergic (DA) substantia nigra pars compacta neurons that displayed caspase-8 activation in Parkinson'...

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Vydáno v:J Neurosci
Hlavní autoři: Hartmann, Andreas, Troadec, Jean-Denis, Hunot, Stéphane, Kikly, Kristy, Faucheux, Baptiste A., Mouatt-Prigent, Annick, Ruberg, Merle, Agid, Yves, Hirsch, Etienne C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2001
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ARTICLE
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762382/
https://ncbi.nlm.nih.gov/pubmed/11264300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-07-02247.2001
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