Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation

Sustained activation of the c-Jun NH(2)-terminal kinase (JNK) signaling pathway mediates the development and progression of experimental diet-induced nonalcoholic fatty liver disease (NAFLD). Delineating the mechanism of JNK overactivation in the setting of a fatty liver is therefore essential to un...

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Main Authors: Singh, Rajat, Wang, Yongjun, Schattenberg, Jörn M., Xiang, Youqing, Czaja, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2009
Assuntos:
Liver and Biliary Tract
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777462/
https://ncbi.nlm.nih.gov/pubmed/20501438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00151.2009
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