Chronic Neuron- and Age-Selective Down-Regulation of TNF Receptor Expression in Triple-Transgenic Alzheimer Disease Mice Leads to Significant Modulation of Amyloid- and Tau-Related Pathologies

Neuroinflammation, through production of proinflammatory molecules and activated glial cells, is implicated in Alzheimer's disease (AD) pathogenesis. One such proinflammatory mediator is tumor necrosis factor α (TNF-α), a multifunctional cytokine produced in excess and associated with amyloid β...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Montgomery, Sara L., Narrow, Wade C., Mastrangelo, Michael A., Olschowka, John A., O'Banion, M. Kerry, Bowers, William J.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Investigative Pathology 2013
الموضوعات:
Regular Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668024/
https://ncbi.nlm.nih.gov/pubmed/23567638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.02.030
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