Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

Alzheimer's disease (AD) is characterized by amyloid-beta (Aβ)-containing plaques, neurofibrillary tangles, and neuron and synapse loss. Tangle formation has been reproduced in P301L tau transgenic pR5 mice, whereas APP(sw)PS2(N141I) double-transgenic APP152 mice develop Aβ plaques. Cross-breed...

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Detalhes bibliográficos
Main Authors: Rhein, Virginie, Song, Xiaomin, Wiesner, Andreas, Ittner, Lars M., Baysang, Ginette, Meier, Fides, Ozmen, Laurence, Bluethmann, Horst, Dröse, Stefan, Brandt, Ulrich, Savaskan, Egemen, Czech, Christian, Götz, Jürgen, Eckert, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774257/
https://ncbi.nlm.nih.gov/pubmed/19897719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905529106
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