Sustained Interleukin-1β Overexpression Exacerbates Tau Pathology Despite Reduced Amyloid Burden in an Alzheimer's Mouse Model

Neuroinflammation is an important component of Alzheimer's disease (AD) pathogenesis and has been implicated in neurodegeneration. Interleukin-1 (IL-1), a potent inflammatory cytokine in the CNS, is chronically upregulated in human AD and believed to serve as part of a vicious inflammatory cycl...

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Главные авторы: Ghosh, Simantini, Wu, Michael D., Shaftel, Solomon S., Kyrkanides, Stephanos, LaFerla, Frank M., Olschowka, John A., O'Banion, M. Kerry
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Neuroscience 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637949/
https://ncbi.nlm.nih.gov/pubmed/23486975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4361-12.2013
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