Sustained hippocampal IL-1β overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology

Neuroinflammation is a conspicuous feature of Alzheimer disease (AD) pathology and is thought to contribute to the ultimate neurodegeneration that ensues. IL-1β has emerged as a prime candidate underlying this response. Here we describe a transgenic mouse model of sustained IL-1β overexpression that...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Shaftel, Solomon S., Kyrkanides, Stephanos, Olschowka, John A., Miller, Jen-nie H., Johnson, Renee E., O’Banion, M. Kerry
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2007
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1878531/
https://ncbi.nlm.nih.gov/pubmed/17549256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31450
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