Sustained hippocampal IL-1β overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology

Neuroinflammation is a conspicuous feature of Alzheimer disease (AD) pathology and is thought to contribute to the ultimate neurodegeneration that ensues. IL-1β has emerged as a prime candidate underlying this response. Here we describe a transgenic mouse model of sustained IL-1β overexpression that...

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Detalhes bibliográficos
Main Authors: Shaftel, Solomon S., Kyrkanides, Stephanos, Olschowka, John A., Miller, Jen-nie H., Johnson, Renee E., O’Banion, M. Kerry
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1878531/
https://ncbi.nlm.nih.gov/pubmed/17549256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31450
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