Transient expression of human adenosine deaminase cDNAs: identification of a nonfunctional clone resulting from a single amino acid substitution.

Human adenosine deaminase (ADA) is an important purine catabolic enzyme which irreversibly deaminates adenosine and deoxyadenosine. Severe genetic deficiency of ADA leads to an immunological deficiency state in which T-lymphoid cells are selectively destroyed by the accumulation of toxic levels of d...

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Publicado en:	Mol Cell Biol
Autores principales:	Orkin, S H, Goff, S C, Kelley, W N, Daddona, P E
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 1985
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC366780/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3838797/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.5.4.762-767.1985
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