Transient expression of human adenosine deaminase cDNAs: identification of a nonfunctional clone resulting from a single amino acid substitution.

Human adenosine deaminase (ADA) is an important purine catabolic enzyme which irreversibly deaminates adenosine and deoxyadenosine. Severe genetic deficiency of ADA leads to an immunological deficiency state in which T-lymphoid cells are selectively destroyed by the accumulation of toxic levels of d...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Orkin, S H, Goff, S C, Kelley, W N, Daddona, P E
Format: Artigo
Language:Inglês
Published: Taylor & Francis 1985
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC366780/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3838797/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.5.4.762
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