Activation of the NLRP3 Inflammasome by IAV Virulence Protein PB1-F2 Contributes to Severe Pathophysiology and Disease

The ability for a host to recognize infection is critical for virus clearance and often begins with induction of inflammation. The PB1-F2 of pathogenic influenza A viruses (IAV) contributes to the pathophysiology of infection, although the mechanism for this is unclear. The NLRP3-inflammasome has be...

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Main Authors: McAuley, Julie L., Tate, Michelle D., MacKenzie-Kludas, Charley J., Pinar, Anita, Zeng, Weiguang, Stutz, Andrea, Latz, Eicke, Brown, Lorena E., Mansell, Ashley
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3667782/
https://ncbi.nlm.nih.gov/pubmed/23737748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003392
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