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Similar 150-kilobase DNA sequences are amplified in independently derived methotrexate-resistant Chinese hamster cells.

We have isolated overlapping recombinant cosmids that represent 150 kilobases of contiguous DNA sequence from the amplified dihydrofolate reductase domain of a methotrexate-resistant Chinese hamster ovary cell line (CHOC 400). This sequence includes the 25-kilobase dihydrofolate reductase gene and a...

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Bibliografische gegevens
Hoofdauteurs: Montoya-Zavala, M, Hamlin, J L
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1985
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC366762/
https://ncbi.nlm.nih.gov/pubmed/2985962
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