Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

Deep vein thrombosis and pulmonary embolism are major health problems associated with high mortality. Recently, DNA-based neutrophil extracellular traps (NETs) resulting from the release of decondensed chromatin, were found to be part of the thrombus scaffold and to promote coagulation. However, the...

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Bibliographic Details
Main Authors: Martinod, Kimberly, Demers, Melanie, Fuchs, Tobias A., Wong, Siu Ling, Brill, Alexander, Gallant, Maureen, Hu, Jing, Wang, Yanming, Wagner, Denisa D.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3666755/
https://ncbi.nlm.nih.gov/pubmed/23650392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301059110
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