A Mini-intronic Plasmid (MIP): A Novel Robust Transgene Expression Vector In Vivo and In Vitro

The bacterial backbone (BB) sequences contained within a canonical plasmid DNA dampen exogenous transgene expression by tenfold to 1,000-fold over a period of a few weeks following transfection into quiescent tissues such as the liver. Minicircle DNA vectors devoid of bacterial plasmid backbone sequ...

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Bibliografiske detaljer
Main Authors: Lu, Jiamiao, Zhang, Feijie, Kay, Mark A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3666631/
https://ncbi.nlm.nih.gov/pubmed/23459514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.33
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