A Rationally Designed A34R Mutant Oncolytic Poxvirus: Improved Efficacy in Peritoneal Carcinomatosis

Oncolytic poxviruses have demonstrated initial promising results in patients with cancer in clinical trials, yet further improvements are needed. It has been shown that a single point mutation in the A34R gene resulted in the production of more total progeny virus and more extracellular enveloped vi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Thirunavukarasu, Pragatheeshwar, Sathaiah, Magesh, Gorry, Michael C, O'Malley, Mark E, Ravindranathan, Roshni, Austin, Frances, Thorne, Steven H, Guo, Zong Sheng, Bartlett, David L
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2013
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3666626/
https://ncbi.nlm.nih.gov/pubmed/23439499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.27
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