Rapid Generation of Multiple Loci-Engineered Marker-free Poxvirus and Characterization of a Clinical-Grade Oncolytic Vaccinia Virus

Recombinant poxviruses, utilized as vaccine vectors and oncolytic viruses, often require manipulation at multiple genetic loci in the viral genome. It is essential for viral vectors to possess no adventitious mutations and no (antibiotic) selection marker in the final product for human patients in o...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Guo, Zong Sheng, Liu, Zuqiang, Sathaiah, Magesh, Wang, Jiahu, Ravindranathan, Roshni, Kim, Eun, Huang, Shaohua, Kenniston, Thomas W., Bell, John C., Zeh, Herbert J., Butterfield, Lisa H., Gambotto, Andrea, Bartlett, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651493/
https://ncbi.nlm.nih.gov/pubmed/29085848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2017.09.007
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