Rapid Generation of Multiple Loci-Engineered Marker-free Poxvirus and Characterization of a Clinical-Grade Oncolytic Vaccinia Virus

Recombinant poxviruses, utilized as vaccine vectors and oncolytic viruses, often require manipulation at multiple genetic loci in the viral genome. It is essential for viral vectors to possess no adventitious mutations and no (antibiotic) selection marker in the final product for human patients in o...

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Veröffentlicht in:Mol Ther Methods Clin Dev
Hauptverfasser: Guo, Zong Sheng, Liu, Zuqiang, Sathaiah, Magesh, Wang, Jiahu, Ravindranathan, Roshni, Kim, Eun, Huang, Shaohua, Kenniston, Thomas W., Bell, John C., Zeh, Herbert J., Butterfield, Lisa H., Gambotto, Andrea, Bartlett, David L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651493/
https://ncbi.nlm.nih.gov/pubmed/29085848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2017.09.007
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