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Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) remains a lethal human malignancy with historically limited success in treatment. The role of aberrant Notch signaling, which requires the constitutive activation of γ-secretase, in the initiation and progression of PDA is well defined and inhibitors of this pa...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3665739/ https://ncbi.nlm.nih.gov/pubmed/23402814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2013.01.054 |
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