Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDA) remains a lethal human malignancy with historically limited success in treatment. The role of aberrant Notch signaling, which requires the constitutive activation of γ-secretase, in the initiation and progression of PDA is well defined and inhibitors of this pa...

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Autores principales: Yabuuchi, Shinichi, Pai, Shweta G., Campbell, Nathaniel R., de F. Wilde, Roeland, De Oliveira, Elizabeth, Korangath, Preethi, Streppel, Mirte, Rasheed, Zeshaan A., Hidalgo, Manuel, Maitra, Anirban, Rajeshkumar, N.V.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3665739/
https://ncbi.nlm.nih.gov/pubmed/23402814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2013.01.054
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