The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy, with most patients facing an adverse clinical outcome. Aberrant Notch pathway activation has been implicated in the initiation and progression of PDAC, specifically the aggressive phenotype of the disease. We used a panel of human PDAC...

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Bibliographic Details
Main Authors:	Mizuma, Masamichi, Rasheed, Zeshaan A., Yabuuchi, Shinichi, Omura, Noriyuki, Campbell, Nathaniel R., de Wilde, Roeland F., De Oliveira, Elizabeth, Zhang, Qing, Puig, Oscar, Matsui, William, Hidalgo, Manuel, Maitra, Anirban, Rajeshkumar, NV
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3438318/ https://ncbi.nlm.nih.gov/pubmed/22752426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0017
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The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models

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