The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy, with most patients facing an adverse clinical outcome. Aberrant Notch pathway activation has been implicated in the initiation and progression of PDAC, specifically the aggressive phenotype of the disease. We used a panel of human PDAC...

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Detaylı Bibliyografya
Asıl Yazarlar: Mizuma, Masamichi, Rasheed, Zeshaan A., Yabuuchi, Shinichi, Omura, Noriyuki, Campbell, Nathaniel R., de Wilde, Roeland F., De Oliveira, Elizabeth, Zhang, Qing, Puig, Oscar, Matsui, William, Hidalgo, Manuel, Maitra, Anirban, Rajeshkumar, NV
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438318/
https://ncbi.nlm.nih.gov/pubmed/22752426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0017
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