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The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy, with most patients facing an adverse clinical outcome. Aberrant Notch pathway activation has been implicated in the initiation and progression of PDAC, specifically the aggressive phenotype of the disease. We used a panel of human PDAC...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Mizuma, Masamichi, Rasheed, Zeshaan A., Yabuuchi, Shinichi, Omura, Noriyuki, Campbell, Nathaniel R., de Wilde, Roeland F., De Oliveira, Elizabeth, Zhang, Qing, Puig, Oscar, Matsui, William, Hidalgo, Manuel, Maitra, Anirban, Rajeshkumar, NV
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2012
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438318/
https://ncbi.nlm.nih.gov/pubmed/22752426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0017
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