The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy, with most patients facing an adverse clinical outcome. Aberrant Notch pathway activation has been implicated in the initiation and progression of PDAC, specifically the aggressive phenotype of the disease. We used a panel of human PDAC...

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Autores principales: Mizuma, Masamichi, Rasheed, Zeshaan A., Yabuuchi, Shinichi, Omura, Noriyuki, Campbell, Nathaniel R., de Wilde, Roeland F., De Oliveira, Elizabeth, Zhang, Qing, Puig, Oscar, Matsui, William, Hidalgo, Manuel, Maitra, Anirban, Rajeshkumar, NV
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438318/
https://ncbi.nlm.nih.gov/pubmed/22752426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0017
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