Therapeutic targeting of the Warburg effect in pancreatic cancer relies on an absence of p53 function

The “Warburg effect” describes a peculiar metabolic feature of many solid tumors, namely their high glycolytic activity for biosynthesis and an inefficient generation of ATP. During aerobic glycolysis, pyruvate is preferentially metabolized to lactate by the enzyme lactate dehydrogenase-A (LDH-A), s...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Rajeshkumar, N.V., Dutta, Prasanta, Yabuuchi, Shinichi, de Wilde, Roeland F., Matrinez, Gary V., Le, Anne, Kamphorst, Jurre J., Rabinowitz, Josh D., Jain, Sanjay K., Hidalgo, Manuel, Dang, Chi V., Gillies, Robert J., Maitra, Anirban
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537812/
https://ncbi.nlm.nih.gov/pubmed/26113084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0108
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