Combination of Oncolytic Herpes Simplex Viruses Armed with Angiostatin and IL-12 Enhances Antitumor Efficacy in Human Glioblastoma Models

Oncolytic herpes simplex virus (oHSV) can potentially spread throughout the tumor, reach isolated infiltrating cells, kill them, and deliver anticancer agents. However, the host responds to oHSV by inducing intratumoral infiltration of macrophages that can engulf the virus, limiting the potential of...

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Main Authors: Zhang, Wei, Fulci, Giulia, Wakimoto, Hiroaki, Cheema, Tooba A, Buhrman, Jason S, Jeyaretna, Deva S, Stemmer Rachamimov, Anat O, Rabkin, Samuel D, Martuza, Robert L
Format: Artigo
Language:Inglês
Published: Neoplasia Press Inc. 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3664991/
https://ncbi.nlm.nih.gov/pubmed/23730207
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