Combination of Oncolytic Herpes Simplex Viruses Armed with Angiostatin and IL-12 Enhances Antitumor Efficacy in Human Glioblastoma Models

Oncolytic herpes simplex virus (oHSV) can potentially spread throughout the tumor, reach isolated infiltrating cells, kill them, and deliver anticancer agents. However, the host responds to oHSV by inducing intratumoral infiltration of macrophages that can engulf the virus, limiting the potential of...

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Detalhes bibliográficos
Main Authors: Zhang, Wei, Fulci, Giulia, Wakimoto, Hiroaki, Cheema, Tooba A, Buhrman, Jason S, Jeyaretna, Deva S, Stemmer Rachamimov, Anat O, Rabkin, Samuel D, Martuza, Robert L
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3664991/
https://ncbi.nlm.nih.gov/pubmed/23730207
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