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Combination of Oncolytic Herpes Simplex Viruses Armed with Angiostatin and IL-12 Enhances Antitumor Efficacy in Human Glioblastoma Models

Oncolytic herpes simplex virus (oHSV) can potentially spread throughout the tumor, reach isolated infiltrating cells, kill them, and deliver anticancer agents. However, the host responds to oHSV by inducing intratumoral infiltration of macrophages that can engulf the virus, limiting the potential of...

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Bibliografische gegevens
Hoofdauteurs: Zhang, Wei, Fulci, Giulia, Wakimoto, Hiroaki, Cheema, Tooba A, Buhrman, Jason S, Jeyaretna, Deva S, Stemmer Rachamimov, Anat O, Rabkin, Samuel D, Martuza, Robert L
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Neoplasia Press Inc. 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3664991/
https://ncbi.nlm.nih.gov/pubmed/23730207
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