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The role of DNA bending in type IIA topoisomerase function
Type IIA topoisomerases control DNA supercoiling and separate newly replicated chromosomes using a complex DNA strand cleavage and passage mechanism. Structural and biochemical studies have shown that these enzymes sharply bend DNA by as much as 150°; an invariant isoleucine, which has been seen str...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3664819/ https://ncbi.nlm.nih.gov/pubmed/23580548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt238 |
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