The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression

The CtIP protein facilitates homology-directed repair (HDR) of double-strand DNA breaks (DSBs) by initiating DNA resection, a process in which DSB ends are converted into 3′-ssDNA overhangs. The BRCA1 tumor suppressor, which interacts with CtIP in a phospho-dependent manner, has also been implicated...

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Bibliografiska uppgifter
Huvudupphovsmän: Reczek, Colleen R., Szabolcs, Matthias, Stark, Jeremy M., Ludwig, Thomas, Baer, Richard
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2013
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3664708/
https://ncbi.nlm.nih.gov/pubmed/23712259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201302145
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