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The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression
The CtIP protein facilitates homology-directed repair (HDR) of double-strand DNA breaks (DSBs) by initiating DNA resection, a process in which DSB ends are converted into 3′-ssDNA overhangs. The BRCA1 tumor suppressor, which interacts with CtIP in a phospho-dependent manner, has also been implicated...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3664708/ https://ncbi.nlm.nih.gov/pubmed/23712259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201302145 |
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