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Structure-Activity Relationship Exploration of Kv1.3 Blockers Based on Diphenoxylate

[Image: see text] Diphenoxylate, a well-known opioid agonist and anti-diarrhoeal agent, was recently found to block Kv1.3 potassium channels, which have been proposed as potential therapeutic targets for a range of autoimmune diseases. The molecular basis for this Kv1.3 blockade was assessed by the...

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Detalhes bibliográficos
Main Authors: Nguyen, William, Howard, Brittany L., Jenkins, David P., Wulff, Heike, Thompson, Philip E., Manallack, David T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3664202/
https://ncbi.nlm.nih.gov/pubmed/23084278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.09.080
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