Mutasynthesis of Fluorinated Pactamycin Analogs and Their Antimalarial Activity

[Image: see text] A mutasynthetic strategy has been used to generate fluorinated TM-025 and TM-026, two biosynthetically engineered pactamycin analogs produced by Streptomyces pactum ATCC 27456. The fluorinated compounds maintain excellent activity and selectivity toward chloroquine-sensitive and mu...

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Main Authors: Almabruk, Khaled H., Lu, Wanli, Li, Yuexin, Abugreen, Mostafa, Kelly, Jane X., Mahmud, Taifo
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663920/
https://ncbi.nlm.nih.gov/pubmed/23521145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol4004614
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