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Mutasynthesis of Fluorinated Pactamycin Analogs and Their Antimalarial Activity
[Image: see text] A mutasynthetic strategy has been used to generate fluorinated TM-025 and TM-026, two biosynthetically engineered pactamycin analogs produced by Streptomyces pactum ATCC 27456. The fluorinated compounds maintain excellent activity and selectivity toward chloroquine-sensitive and mu...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3663920/ https://ncbi.nlm.nih.gov/pubmed/23521145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol4004614 |
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