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Alzheimer’s disease: Which type of amyloid-preventing drug agents to employ?

The current paradigm in the amyloid hypothesis brands small β-amyloid (Aβ) oligomers as the toxic species in Alzheimer’s disease (AD). These oligomers are fibril-like; contain β-sheet structure, and present exposed hydrophobic surface. Oligomers with this motif are capable of penetrating the cell me...

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Main Authors: Jang, Hyunbum, Connelly, Laura, Arce, Fernando Teran, Ramachandran, Srinivasan, Lal, Ratnesh, Kagan, Bruce L., Nussinov, Ruth
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663909/
https://ncbi.nlm.nih.gov/pubmed/23450150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cp00017f
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