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Photoreceptor Proteins Initiate Microglial Activation via Toll-like Receptor 4 in Retinal Degeneration Mediated by All-trans-retinal

Although several genetic and biochemical factors are associated with the pathogenesis of retinal degeneration, it has yet to be determined how these different impairments can cause similar degenerative phenotypes. Here, we report microglial/macrophage activation in both a Stargardt disease and age-r...

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Autori principali: Kohno, Hideo, Chen, Yu, Kevany, Brian M., Pearlman, Eric, Miyagi, Masaru, Maeda, Tadao, Palczewski, Krzysztof, Maeda, Akiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663552/
https://ncbi.nlm.nih.gov/pubmed/23572532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.448712
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