Toll-like Receptor 3 Is Required for Development of Retinopathy Caused by Impaired All-trans-retinal Clearance in Mice

Chronic inflammation is an important component that contributes to many age-related neurodegenerative diseases, including macular degeneration. Here, we report a role for toll-like receptor 3 (TLR3) in cone-rod dystrophy (CORD) of mice lacking ATP-binding cassette transporter 4 (ABCA4) and retinol d...

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Bibliografiske detaljer
Main Authors: Shiose, Satomi, Chen, Yu, Okano, Kiichiro, Roy, Sanhita, Kohno, Hideo, Tang, Johnny, Pearlman, Eric, Maeda, Tadao, Palczewski, Krzysztof, Maeda, Akiko
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083179/
https://ncbi.nlm.nih.gov/pubmed/21383019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.228551
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