A Lipoprotein Receptor Cluster IV Mutant Preferentially Binds Amyloid-β and Regulates Its Clearance from the Mouse Brain

Soluble low density lipoprotein receptor-related protein-1 (sLRP1) binds ∼70% of amyloid β-peptide (Aβ) in human plasma. In Alzheimer disease (AD) and individuals with mild cognitive impairment converting to AD, plasma sLRP1 levels are reduced and sLRP1 is oxidized, which results in diminished Aβ pe...

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Main Authors: Sagare, Abhay P., Bell, Robert D., Srivastava, Alaka, Sengillo, Jesse D., Singh, Itender, Nishida, Yoichiro, Chow, Nienwen, Zlokovic, Berislav V.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2013
主題:
Neurobiology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663536/
https://ncbi.nlm.nih.gov/pubmed/23580652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.439570
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