SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells

Amyloid β-peptide (Aβ) deposition in cerebral vessels contributes to cerebral amyloid angiopathy (CAA) in Alzheimer’s disease (AD). Here, we report that in AD patients and two mouse models of AD, overexpression of serum response factor (SRF) and myocardin (MYOCD) in cerebral vascular smooth muscle c...

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Bibliografski detalji
Glavni autori: Bell, Robert D., Deane, Rashid, Chow, Nienwen, Long, Xiaochun, Sagare, Abhay, Singh, Itender, Streb, Jeffrey W., Guo, Huang, Rubio, Anna, Van Nostrand, William, Miano, Joseph M., Zlokovic, Berislav V.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654279/
https://ncbi.nlm.nih.gov/pubmed/19098903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1819
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