Coordinated Processing of 3′ Slipped (CAG)(n)/(CTG)(n) Hairpins by DNA Polymerases β and δ Preferentially Induces Repeat Expansions

Expansion of CAG/CTG trinucleotide repeats causes certain familial neurological disorders. Hairpin formation in the nascent strand during DNA synthesis is considered a major path for CAG/CTG repeat expansion. However, the underlying mechanism is unclear. We show here that removal or retention of a n...

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Hlavní autoři: Chan, Nelson L. S., Guo, Jinzhen, Zhang, Tianyi, Mao, Guogen, Hou, Caixia, Yuan, Fenghua, Huang, Jian, Zhang, Yanbin, Wu, Jianxin, Gu, Liya, Li, Guo-Min
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
DNA and Chromosomes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663522/
https://ncbi.nlm.nih.gov/pubmed/23585564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.464370
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